Molecular Formula | C25H41NaO6
|
Molar Mass | 460.59 |
Melting Point | >122°C (dec.) |
Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
Appearance | White powder solid. |
Color | White to Pale Beige |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
In vitro study | Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts.Simvastatin sodium (100 μM) inhibits the Na + /H + antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene. |
In vivo study | Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia. |